2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline
CAS No.:263570-36-1
Molecular Formula:C₂₄H₂₈INO₃Si
Molecular Weight:533.481
Hs Code.:

Synonyms:2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about 2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 609-67-6
2-Iodobenzoyl chloride

: 263570-34-9
tert-butyl 6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

: 263570-36-1
2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With dmap; trimethylsilyl iodide; triethylamine; In methanol; acetonitrile; benzene; at 20 ℃;

Reference yield:

: 734534-07-7
tert-butyl 1-(2-ethoxy-2-oxoethyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2-(1H)-carboxylate

: 263570-36-1
2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

2: 87 percent / Et₃N; SO₃-pyridine / dimethylsulfoxide; CH₂Cl₂ / 2 h / 0 °C

3: 62 percent / triphenylphosphine / potassium tert-butoxide / toluene / 1 h / -20 °C

4: 75 percent / TMEDA; n-BuLi / tetrahydrofuran; hexane / 20 °C

5: 94 percent / TMS-I; Et₃N; DMAP / methanol; benzene; acetonitrile / 20 °C

With dmap; lithium aluminium tetrahydride; n-butyllithium; pyridine-SO₃ complex; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; triethylamine; triphenylphosphine; potassium tert-butylate; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile; benzene;

Reference yield:

: 14028-68-3
ethyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

: 263570-36-1
2-(o-iodobenzoyl)-6,7-dimethoxy-1-[3-(trimethylsilyl)prop-2-ynyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / DMAP; Et₃N / acetonitrile / 10 h / 20 °C

2: LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

3: 87 percent / Et₃N; SO₃-pyridine / dimethylsulfoxide; CH₂Cl₂ / 2 h / 0 °C

4: 62 percent / triphenylphosphine / potassium tert-butoxide / toluene / 1 h / -20 °C

5: 75 percent / TMEDA; n-BuLi / tetrahydrofuran; hexane / 20 °C

6: 94 percent / TMS-I; Et₃N; DMAP / methanol; benzene; acetonitrile / 20 °C

With dmap; lithium aluminium tetrahydride; n-butyllithium; pyridine-SO₃ complex; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; triethylamine; triphenylphosphine; potassium tert-butylate; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile; benzene;