Chemical Property of Nysted Reagent
Chemical Property:
- Flash Point:15 ºF
- PSA：9.23000
- Density:1.186 g/mL at 25 ºC(lit.)
- LogP:3.40210
- Purity/Quality:
-
99% *data from raw suppliers
Nysted Reagent
20 wt. % suspension in THF *data from reagent suppliers
Safty Information:
- Pictogram(s):
F,
Xn
- Hazard Codes:F,Xn
- Statements:
11-14-19-22-36/37/38-40-36/37
- Safety Statements:
16-26-36-36/37
- MSDS Files:
-
SDS file from LookChem
Useful:
-
Uses
Nysted Reagent is a reagent used in synthetic reactions such as the synthesis of Entcavir. Reagent for the methylenation of ketones and aldehydes. The cyclo-dibromo-di-m-methylene-(m-tetrahydrofuran)-trizinc is known as the Nysted reagent. This reagent is prepared by treatment of dibromomethane with activated zinc-lead couple or hydrogen chloride-activated zinc dust in THF. This reagent is useful for converting a carbonyl group into a methylene group, and such transformation is known as the Nysted methylenation or Nysted olefination. The study finds that this reagent is superior to the Tebbe reagent.
