Nysted Reagent

Base Information

• Chemical Name: Nysted Reagent
• CAS No.: 41114-59-4
• Molecular Formula: C6H12Br2OZn3
• Molecular Weight: 456.14
• Mol file: 41114-59-4.mol

Synonyms:Nysted'sreagent;

Chemical Property of Nysted Reagent

Chemical Property:

• Flash Point: 15 ºF
• PSA: 9.23000
• Density: 1.186 g/mL at 25 ºC(lit.)
• LogP: 3.40210

Purity/Quality:

99% ^*data from raw suppliers

Nysted Reagent 20 wt. % suspension in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn
• Statements: 11-14-19-22-36/37/38-40-36/37
• Safety Statements: 16-26-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Nysted Reagent is a reagent used in synthetic reactions such as the synthesis of Entcavir. Reagent for the methylenation of ketones and aldehydes. The cyclo-dibromo-di-m-methylene-(m-tetrahydrofuran)-trizinc is known as the Nysted reagent. This reagent is prepared by treatment of dibromomethane with activated zinc-lead couple or hydrogen chloride-activated zinc dust in THF. This reagent is useful for converting a carbonyl group into a methylene group, and such transformation is known as the Nysted methylenation or Nysted olefination. The study finds that this reagent is superior to the Tebbe reagent.