[1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide]

Base Information

Chemical Name:[1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide]
CAS No.:1039540-14-1
Molecular Formula:C₃₉H₅₅N₅O₁₀SSi₂
Molecular Weight:842.13
Hs Code.:

[1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide]

Synonyms:[1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide]

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Chemical Property of [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide]

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Technology Process of [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide]

There total 1 articles about [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 103-71-9
phenyl isocyanate

: 142102-79-2
TSAO-m3T

: 1039540-07-2
[1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide]

: 1039540-14-1
[1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide]

Guidance literature:: TSAO-m3T; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

phenyl isocyanate; In tetrahydrofuran; mineral oil; at 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/jm800050t