9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate

Base Information

• Chemical Name: 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate
• CAS No.: 76988-66-4
• Molecular Formula: C₂₀H₁₃Cl₂N₃O₂
• Molecular Weight: 398.248

Synonyms:9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate

Chemical Property of 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate

Chemical Property:

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Technology Process of 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate

There total 2 articles about 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acetic anhydride (108-24-7) + 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine 6-oxide (76988-65-3) → 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate (76988-66-4)

Guidance literature:

at 100 ℃; for 22h;

DOI:10.1021/jm00365a009

Reference yield:

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-39-1) → 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate (76988-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / 85percent m-chloroperbenzoic acid (m-CPBA) / CH₂Cl₂ / 4 h / Ambient temperature

2: 86 percent / 22 h / 100 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jm00365a009

Reference yield: 95.0%

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol acetate (76988-66-4) → 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol (76988-67-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; for 0.5h; Ambient temperature;

DOI:10.1021/jm00365a009

upstream raw materials:

acetic anhydride

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine 6-oxide

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine

Downstream raw materials:

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-5-ol

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