(3S)-3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetatic acid1,2-dimeth

Base Information

Chemical Name:(3S)-3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetatic acid1,2-dimeth
CAS No.:182561-27-9
Molecular Formula:C₄H₆O₆*C₁₆H₂₂N₂O₃
Molecular Weight:440.45
Hs Code.:
Mol file:182561-27-9.mol

Synonyms:(3S)-3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetatic acid1,2-dimeth;(3S)-3-Amino-2,3,4,5-Tetrahydro-2-Oxo-1h-1-Benzazepine-1-Acetatic Acid1,2-Dimethylethyl Ester, (2r,3r)-2,3-Dihydroxybutanedioate;(3S)-3-Amino-2,3,4,5-Tetrahydro-2-Oxo-1H-1-Benzazepine-1-AcetaticAcid1,2-DimethylethylEster,(2R,3R)-2,3-Dihydroxybutanedioate(1:1)

Suppliers and Price of (3S)-3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetatic acid1,2-dimeth

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 18 raw suppliers

Chemical Property of (3S)-3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetatic acid1,2-dimeth

Chemical Property:

PSA：187.69000
LogP:0.27750

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S)-3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetatic acid1,2-dimeth

There total 5 articles about (3S)-3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetatic acid1,2-dimeth which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 87-69-4,138508-61-9
L-Tartaric acid

: 98626-45-0
1-tert-butoxycarbonylmethyl-3S-amino-2,3,4,5-tetrahydro-1H-⁽¹⁾-benzazepin-2-one

: 182561-27-9
(S)-1-t-butyloxycarbonylmethyl-3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one tartrate salt

Guidance literature:: With benzaldehyde; In ethanol; for 14h; Heating;
DOI:10.1002/hlca.19880710205

Reference yield:

: 86499-96-9
3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

: 182561-27-9
(S)-1-t-butyloxycarbonylmethyl-3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one tartrate salt

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / dimethylformamide / 16 h / 60 °C

2: 93 percent / kalium-(tert-butylat) / dimethylformamide / 1 h / 0 - 5 °C

3: 85 percent / 2-aminoethanol / 0.08 h / 80 °C

4: 79 percent / C₆H₅CHO / ethanol / 14 h / Heating

With potassium tert-butylate; benzaldehyde; ethanolamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19880710205

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 182561-27-9
(S)-1-t-butyloxycarbonylmethyl-3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one tartrate salt

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / kalium-(tert-butylat) / dimethylformamide / 1 h / 0 - 5 °C

2: 85 percent / 2-aminoethanol / 0.08 h / 80 °C

3: 79 percent / C₆H₅CHO / ethanol / 14 h / Heating

With potassium tert-butylate; benzaldehyde; ethanolamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19880710205