Technology Process of DL-1,3,5-tri-O-benzoyl-scyllo-inositol 2,4,6-tris(diethyl phosphonate)
There total 6 articles about DL-1,3,5-tri-O-benzoyl-scyllo-inositol 2,4,6-tris(diethyl phosphonate) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl phosphorylchloridite; 1,3,5-tri-O-benzoyl-scyllo-inositol;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 8h;
With
dihydrogen peroxide;
In
phosphate buffer;
at 20 ℃;
pH=7;
DOI:10.1016/S0968-0896(99)00183-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 96 percent / H2 / Pd(OH)2/C / CH2Cl2; ethanol / 24 h / 2585.74 Torr
2.1: TSA / dimethylformamide / 12 h / 100 °C
3.1: 186 percent / pyridine / 24 h / 100 °C
4.1: 87 percent / TSA / methanol / Heating
5.1: iPr2NEt / dimethylformamide / 8 h / 20 °C
5.2: 85 percent / aq. H2O2 / aq. phosphate buffer / 20 °C / pH 7
With
pyridine; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium dihydroxide;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
1.1: Catalytic hydrogenation / 2.1: Condensation / 3.1: Acylation / 4.1: Hydrolysis / 5.1: phosphorylation / 5.2: Oxidation;
DOI:10.1016/S0968-0896(99)00183-2
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 72 percent / PPh3; DEAD / benzene / 4 h / 80 °C
2.1: 96 percent / H2 / Pd(OH)2/C / CH2Cl2; ethanol / 24 h / 2585.74 Torr
3.1: TSA / dimethylformamide / 12 h / 100 °C
4.1: 186 percent / pyridine / 24 h / 100 °C
5.1: 87 percent / TSA / methanol / Heating
6.1: iPr2NEt / dimethylformamide / 8 h / 20 °C
6.2: 85 percent / aq. H2O2 / aq. phosphate buffer / 20 °C / pH 7
With
pyridine; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
palladium dihydroxide;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
1.1: Acylation / 2.1: Catalytic hydrogenation / 3.1: Condensation / 4.1: Acylation / 5.1: Hydrolysis / 6.1: phosphorylation / 6.2: Oxidation;
DOI:10.1016/S0968-0896(99)00183-2
