N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide

Base Information

Chemical Name:N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide
CAS No.:1346568-83-9
Molecular Formula:C₂₇H₂₃ClN₂O₂
Molecular Weight:442.945
Hs Code.:

Synonyms:N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide

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Chemical Property of N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide

Chemical Property:

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Technology Process of N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide

There total 7 articles about N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine hydrochloride

: 64-19-7,77671-22-8
acetic acid

: 1346568-83-9
N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 22 - 26 ℃; for 4h;

Reference yield:

: 1346570-28-2
2-({4-[3-chloro-1-(4-chlorophenyl)prop-1-en-2-yl]phenoxy}methyl)quinoline

: 1346568-83-9
N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide / N,N-dimethyl-formamide / 60 °C

2: triphenylphosphine / tetrahydrofuran / 3 h / 22 - 26 °C

3: triethylamine / acetonitrile; water / 6 h / 22 - 26 °C

4: hydrogenchloride / ethyl acetate

5: triethylamine / dichloromethane / 4 h / 22 - 26 °C

With hydrogenchloride; sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₂₇H₂₂ClNO₃

: 1346568-83-9
N-{3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -40 - -30 °C

1.2: 0.5 h

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 °C

3.1: sodium azide / N,N-dimethyl-formamide / 60 °C

4.1: triphenylphosphine / tetrahydrofuran / 3 h / 22 - 26 °C

5.1: triethylamine / acetonitrile; water / 6 h / 22 - 26 °C

6.1: hydrogenchloride / ethyl acetate

7.1: triethylamine / dichloromethane / 4 h / 22 - 26 °C

With hydrogenchloride; sodium azide; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;