{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid

Base Information

Chemical Name:{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid
CAS No.:1420069-68-6
Molecular Formula:C₂₃H₂₂F₃N₃O₃
Molecular Weight:445.441
Hs Code.:

Synonyms:{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid

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Chemical Property of {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid

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Technology Process of {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid

There total 5 articles about {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1420068-64-9
tert-butyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetate

: 1420069-68-6
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 271-44-3
benzimidazole

: 1420069-68-6
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; sodium hydroxide / methanol / 48 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube

4: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; caesium carbonate; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 66607-27-0
3-iodoindazole

: 1420069-68-6
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indazol-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube

3: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;