N-Boc-N'-benzyloxymethyl-L-histidine

Base Information

Chemical Name:N-Boc-N'-benzyloxymethyl-L-histidine
CAS No.:79950-65-5
Molecular Formula:C19H25 N3 O5
Molecular Weight:375.425
Hs Code.:
European Community (EC) Number:692-757-4
Mol file:79950-65-5.mol

Synonyms:N-(tert-Butoxy)carbonyl-N'-benzyloxymethyl-L-histidine; Boc-His(Bom)-OH

Suppliers and Price of N-Boc-N'-benzyloxymethyl-L-histidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Boc-His(Bom)-OH 95+%
5g
$ 161.00

Matrix Scientific
Boc-His(Bom)-OH 95+%
25g
$ 435.00

Crysdot
Boc-His(Bom)-OH 96%
100g
$ 356.00

chempep
Boc-His(Bom)-OH >=98%
25g
$ 296.00

chempep
Boc-His(Bom)-OH >=98%
100g
$ 735.00

Chem-Impex
Boc-His(3-Bom)-OH,≥98.5%(HPLC) ≥98.5%(HPLC)
100G
$ 850.30

Chem-Impex
Boc-His(3-Bom)-OH,98.5%(HPLC) 98.5%(HPLC)
25G
$ 308.00

Chem-Impex
Boc-His(3-Bom)-OH,98.5%(HPLC) 98.5%(HPLC)
1G
$ 22.40

Chem-Impex
Boc-His(3-Bom)-OH ≥ 98.5% (HPLC)
5G
$ 70.00

Chemenu
Nalpha-Boc-3-[(benzyloxy)methyl]-L-histidine 96%
25g
$ 122.00

Total 47 raw suppliers

Chemical Property of N-Boc-N'-benzyloxymethyl-L-histidine

Chemical Property:

Vapor Pressure:5.11E-15mmHg at 25°C
Melting Point:122-125 ºC
Boiling Point:595.3oC at 760 mmHg
PKA:3.55±0.10(Predicted)
Flash Point:313.8oC
PSA：102.68000
Density:1.21g/cm3
LogP:2.96870
Storage Temp.:2-8°C
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:375.17942091
Heavy Atom Count:27
Complexity:488

Purity/Quality:

99% ^*data from raw suppliers

Boc-His(Bom)-OH 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CN=CN1COCC2=CC=CC=C2)C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC1=CN=CN1COCC2=CC=CC=C2)C(=O)O
Uses Boc-L-His(Bom)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Technology Process of N-Boc-N'-benzyloxymethyl-L-histidine

There total 6 articles about N-Boc-N'-benzyloxymethyl-L-histidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 83468-80-8
N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidine methyl ester hydrochloride

: 79950-65-5,99310-01-7
N-[(1,1-dimethylethoxy)carbonyl]-3-[(phenylmethoxy)methyl]-L-histidine

Guidance literature:: With sodium hydroxide; In methanol; for 0.25h;

Reference yield: 78.0%

: 79950-77-9
N^α-tert-Boc-N^?-<(benzyloxy)methyl>-L-histidine methyl ester

: 79950-65-5,99310-01-7
N-[(1,1-dimethylethoxy)carbonyl]-3-[(phenylmethoxy)methyl]-L-histidine

Guidance literature:: With sodium hydroxide;
DOI:10.1039/c39810000648

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 79950-65-5,99310-01-7
N-[(1,1-dimethylethoxy)carbonyl]-3-[(phenylmethoxy)methyl]-L-histidine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / methanol

2: 69 percent / CH₂Cl₂

3: 87 percent / aq. NaOH / methanol / 0.25 h

With sodium hydroxide; triethylamine; In methanol; dichloromethane;