4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile

Base Information

Chemical Name:4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile
CAS No.:1202041-97-1
Molecular Formula:C₁₉H₁₈Cl₂N₄OS
Molecular Weight:421.35
Hs Code.:

Synonyms:4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile

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Chemical Property of 4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile

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Technology Process of 4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile

There total 7 articles about 4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1202041-96-0
4-(2,4-dichlorophenyl)-5-formyl-2-morpholinothiophene-3-carbonitrile

: 78-90-0,10424-38-1
1,2-diaminopropan

: 1202041-97-1
4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile

Guidance literature:: 4-(2,4-dichlorophenyl)-5-formyl-2-morpholinothiophene-3-carbonitrile; 1,2-diaminopropan; In tert-butyl alcohol; for 0.5h;

With iodine; potassium carbonate; In tert-butyl alcohol; at 70 ℃; for 3h;

Reference yield:

: 1202041-94-8
4-cyano-3-(2,4-dichlorophenyl)-5-morpholin-4-ylthiophene-2-carboxylic acid chloride

: 1202041-97-1
4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 0 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.58 h / -78 - 0 °C

2.2: -78 °C

3.1: tert-butyl alcohol / 0.5 h

3.2: 3 h / 70 °C

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; tert-butyl alcohol;

Reference yield:

: 1174304-59-6
C₁₄H₁₂Cl₂N₂O₂S

: 1202041-97-1
4-(2,4-dichlorophenyl)-5-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-2-morpholinothiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 h / 20 °C

3.1: thionyl chloride / toluene / 1 h / 80 °C

4.1: triethylamine / dichloromethane / 1 h / 0 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.58 h / -78 - 0 °C

5.2: -78 °C

6.1: tert-butyl alcohol / 0.5 h

6.2: 3 h / 70 °C

With thionyl chloride; water; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile; tert-butyl alcohol;