20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate

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Chemical Name:20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate
CAS No.:1310344-41-2
Molecular Formula:C₃₇H₄₇F₇N₂O₅
Molecular Weight:732.779
Hs Code.:

Synonyms:20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate

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Chemical Property of 20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate

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Technology Process of 20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate

There total 3 articles about 20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1310344-39-8
N-[20S-(dimethylamino)-16α-hydroxy-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-3β-yl]-heptafluoroisobutanamide

: 93-97-0
benzoic acid anhydride

: 1310344-41-2
20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 13h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.02.073

Reference yield:

: N-[(3β,4α,9β,16α,20S)-20-(dimethylamino)-16-hydroxy-4-(hydroxymethyl)-4,14-dimethyl-11-oxo-9,19-cyclopregnan-3-yl]-2-methylpropanamide

: 1310344-41-2
20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / methanol

2: methanol / 12 h / 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 13 h / 0 - 20 °C / Inert atmosphere

With pyridine; sulfuric acid; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.073

Reference yield:

: 14155-67-0
(3β,4α,9β,16α,20S)-3-amino-20-(dimethylamino)-16-hydroxy-4-(hydroxymethyl)-4,14-dimethyl-9,19-cyclopregnan-11-one

: 1310344-41-2
20S-(dimethylamino)-3β-(heptafluoroisobutanamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 12 h / 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 13 h / 0 - 20 °C / Inert atmosphere

With pyridine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.073