1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione

Base Information

Chemical Name:1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione
CAS No.:133470-88-9
Molecular Formula:C₂₃H₂₃N₃O₁₀
Molecular Weight:501.45
Hs Code.:

Synonyms:1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione

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Chemical Property of 1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione

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Technology Process of 1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione

There total 5 articles about 1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 133470-85-6
1,benzyl-2',3',5'-tri-O-acetylpyrazofurin

: 530-62-1
1,1'-carbonyldiimidazole

: 133470-88-9
1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 60 ℃; for 1h;
DOI:10.1021/jm00111a005

Reference yield:

: 100-39-0
benzyl bromide

: 133470-88-9
1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / Na₂CO₃ / H₂O; acetonitrile / 144 h / Ambient temperature

2: pyridine / 3.5 h / Ambient temperature

3: H₂ / 20percent Pd/C / ethanol / 2585.7 Torr / Ambient temperature

4: 68 percent / NaH / tetrahydrofuran / 1 h / 60 °C

With pyridine; hydrogen; sodium hydride; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1021/jm00111a005

Reference yield:

: 133470-82-3
1,4-O-dibenzylpyrazofurin

: 133470-88-9
1-benzyl-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-e><1,3>oxazine-5,7-dione

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 3.5 h / Ambient temperature

2: H₂ / 20percent Pd/C / ethanol / 2585.7 Torr / Ambient temperature

3: 68 percent / NaH / tetrahydrofuran / 1 h / 60 °C

With pyridine; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00111a005