5-Methoxypyridin-3-amine

Base Information

• Chemical Name: 5-Methoxypyridin-3-amine
• CAS No.: 64436-92-6
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 2933399090
• European Community (EC) Number: 696-478-9
• DSSTox Substance ID: DTXSID70507430
• Nikkaji Number: J3.628.536B
• Wikidata: Q72438970
• Mol file: 64436-92-6.mol

Synonyms:3-Amino-5-methoxypyridine;64436-92-6;5-methoxypyridin-3-amine;5-Methoxy-pyridin-3-ylamine;3-Amino-5-methoxy-pyridine;MFCD09701369;3-PYRIDINAMINE, 5-METHOXY-;5-Methoxypyridin-3-ylamine;5-amino-3-methoxy pyridine;5-methoxyl-pyridin-3-ylamine;SCHEMBL113446;5-METHOXY-3-PYRIDYLAMINE;DTXSID70507430;CTQPCFFQBYXOAJ-UHFFFAOYSA-N;BCP22617;AKOS005146173;3-Amino-5-methoxypyridine, AldrichCPR;AC-3066;CS-W003621;GS-6605;PB12653;SY003728;A8825;AM20061789;BB 0261701;FT-0648669;EN300-95404;J-517709

Chemical Property of 5-Methoxypyridin-3-amine

Chemical Property:

• Vapor Pressure: 0.00147mmHg at 25°C
• Melting Point: 64-65 °C(Solv: benzene (71-43-2))
• Refractive Index: 1.56
• Boiling Point: 296.1 °C at 760 mmHg
• PKA: 5.80±0.10(Predicted)
• Flash Point: 132.9 °C
• PSA: 48.14000
• Density: 1.139 g/cm³
• LogP: 1.25360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99.5% ^*data from raw suppliers

5-Methoxypyridin-3-amine 95% ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CN=CC(=C1)N

Technology Process of 5-Methoxypyridin-3-amine

There total 20 articles about 5-Methoxypyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-amino-5-methoxypyridine N-oxide (78156-40-8) → 3-amino-5-methoxypyridine (64436-92-6)

Guidance literature:

With hydrogen; nickel; In methanol; for 1h; Ambient temperature;

Reference yield: 91.0%

3-bromo-5-methoxypyridine (50720-12-2) → bis(5-methoxypyridin-3-yl)amine (1445972-34-8) + 3-amino-5-methoxypyridine (64436-92-6)

Guidance literature:

With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C₅₀H₇₀NO₄PPdS; C₅₀H₇₀NO₄PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol401612c

Reference yield: 82.0%

3-bromo-5-methoxypyridine (50720-12-2) → 3-amino-5-methoxypyridine (64436-92-6)

Guidance literature:

With ammonium hydroxide; copper(II) sulfate; at 130 ℃;

DOI:10.1021/op300064b

upstream raw materials:

3-acetamido-5-methoxypyridine

2,6-dibromo-3-methoxy-5-nitropyridine

3-amino-5-methoxypyridine N-oxide

3,5-dibromopyridine-N-oxide

Downstream raw materials:

methyl 2-{[(5-methoxypyridin-3-yl)amino]sulfonyl}benzoate

methyl 2-{[(4-methoxypyridin-3-yl)amino]sulfonyl}benzoate

2,6-dichloro-5-methoxypyridin-3-amine

2-[2-methoxy-4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl]acetic acid

Refernces

• 1、 -. "Aurora Kinase Modulators and Method of Use". Paragraph 0315. . Retrieved 2014/11/27.
• 2、 Cheung, Chi Wai,Surry, David S.,Buchwald, Stephen L.. "Mild and highly selective palladium-catalyzed monoarylation of ammonia enabled by the use of bulky biarylphosphine ligands and palladacycle precatalysts". supporting information. p. 3734 - 3737. Retrieved 2013/08/23.