2,6-Dibromo-3-methoxy-5-nitropyridine

Base Information

• Chemical Name: 2,6-Dibromo-3-methoxy-5-nitropyridine
• CAS No.: 79491-46-6
• Molecular Formula: C₆H₄Br₂N₂O₃
• Molecular Weight: 311.917
• Hs Code.: 2933399090
• European Community (EC) Number: 813-542-5
• DSSTox Substance ID: DTXSID70509111
• Wikidata: Q82366477
• Mol file: 79491-46-6.mol

Synonyms:2,6-Dibromo-3-methoxy-5-nitropyridine;79491-46-6;MFCD18632733;C6H4Br2N2O3;SCHEMBL2144114;DTXSID70509111;UHFLJHCYEBYJIT-UHFFFAOYSA-N;AKOS016012770;DS-5336;SY322916;CS-0110161;FT-0714862;EN300-173777;2 pound not6-Dibromo-3-methoxy-5-nitropyridine;A864848

Chemical Property of 2,6-Dibromo-3-methoxy-5-nitropyridine

Chemical Property:

• Melting Point: 113-114 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 342.5±37.0 °C(Predicted)
• PKA: -12.06±0.10(Predicted)
• PSA: 67.94000
• Density: 2.067±0.06 g/cm3(Predicted)
• LogP: 3.04660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 311.85682
• Heavy Atom Count: 13
• Complexity: 199

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dibromo-3-methoxy-5-nitropyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(N=C(C(=C1)[N+](=O)[O-])Br)Br

Technology Process of 2,6-Dibromo-3-methoxy-5-nitropyridine

There total 4 articles about 2,6-Dibromo-3-methoxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2,6-dibromo-3-methoxylpyridine (79491-45-5) → 2,6-dibromo-3-methoxy-5-nitropyridine (79491-46-6)

Guidance literature:

With sulfuric acid; nitric acid; at 60 - 65 ℃; for 2h;

Reference yield:

2,6-dibromopyridin-3-ol (6602-33-1) → 2,6-dibromo-3-methoxy-5-nitropyridine (79491-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating

2: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C

With sulfuric acid; nitric acid; potassium carbonate; In dimethyl sulfoxide;

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) → 2,6-dibromo-3-methoxy-5-nitropyridine (79491-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; sodium hydroxide / 5 h / 0 - 20 °C

2: potassium carbonate / dimethyl sulfoxide / 2 h / Reflux

3: sulfuric acid; nitric acid / 36 h / 0 - 65 °C

With sulfuric acid; bromine; nitric acid; potassium carbonate; sodium hydroxide; In dimethyl sulfoxide;

DOI:10.1016/j.bmc.2014.05.021

upstream raw materials:

2,6-dibromo-3-methoxylpyridine

3-HYDROXYPYRIDINE

2,6-dibromopyridin-3-ol

Downstream raw materials:

2-bromo-5,6-dimethoxy-3-nitropyridine

3-amino-5,6-dimethoxypyridine

2,6-dibromo-5-methoxypyridin-3-amine

3-amino-5-methoxypyridine