4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester

Base Information

Chemical Name:4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester
CAS No.:1187321-31-8
Molecular Formula:C₂₁H₃₀N₂O₆
Molecular Weight:406.479
Hs Code.:

Synonyms:4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester

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Chemical Property of 4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester

There total 1 articles about 4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093214-64-2
1-(tert-butoxycarbonyl)-4-(ethoxycarbonyl)piperidine-4-carboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1187321-31-8
4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester

Guidance literature:: 1-(tert-butoxycarbonyl)-4-(ethoxycarbonyl)piperidine-4-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 20 ℃; for 0.75h;

benzyl alcohol; In toluene; at 80 ℃; for 20h;

Reference yield:

: 1187321-31-8
4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester

: 917834-41-4
tert-butyl 4-(benzyloxycarbonylamino)-4-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethanol / 2.25 h

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 0 - 5 °C

2.2: 0.25 h / 0 - 5 °C

3.1: triethylamine / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol;

Reference yield:

: 1187321-31-8
4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester

: 1187321-35-2
(4-fluoromethylpiperidin-4-yl)carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethanol / 2.25 h

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 0 - 5 °C

2.2: 0.25 h / 0 - 5 °C

3.1: triethylamine / tetrahydrofuran / 0 - 20 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 5 °C / Inert atmosphere

5.1: hydrogenchloride; water / 1,4-dioxane / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; water; hydrogen; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;