(S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

Base Information

Chemical Name:(S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone
CAS No.:335160-65-1
Molecular Formula:C₂₁H₃₀N₂O₅
Molecular Weight:390.48
Hs Code.:

Synonyms:(S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

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Chemical Property of (S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

Chemical Property:

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Technology Process of (S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

There total 6 articles about (S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 335160-63-9
(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

: 335160-65-1
(S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 2h;
DOI:10.1021/ol015504w

Reference yield:

: 20781-21-9
2,4-dimethoxybenzylamine hydrochloride

: 335160-65-1
(S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 14 h / 20 °C

2: 93 percent / NaHCO₃ / ethyl acetate; H₂O / 0.33 h / 0 °C

3: 75 percent / Cs₂CO₃ / dimethylformamide / 2 h / 65 °C

With 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; caesium carbonate; In water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ol015504w

Reference yield:

: 95107-99-6
tert-butyl (S)-(1-oxopent-4-en-2-yl)carbamate

: 335160-65-1
(S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 14 h / 20 °C

2: 93 percent / NaHCO₃ / ethyl acetate; H₂O / 0.33 h / 0 °C

3: 75 percent / Cs₂CO₃ / dimethylformamide / 2 h / 65 °C

With 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; caesium carbonate; In water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ol015504w