(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

Base Information

Chemical Name:(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate
CAS No.:335160-63-9
Molecular Formula:C₂₁H₃₁ClN₂O₅
Molecular Weight:426.941
Hs Code.:

Synonyms:(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

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Technology Process of (1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

There total 5 articles about (1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 79-04-9
chloroacetyl chloride

: 335160-61-7
(1S)-tert-butyl-1-{[(2,4-dimethoxybenzyl)amino]methyl}but-3-enylcarbamate

: 335160-63-9
(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 ℃; for 0.333333h;
DOI:10.1021/ol015504w

Reference yield:

: 20781-21-9
2,4-dimethoxybenzylamine hydrochloride

: 335160-63-9
(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 14 h / 20 °C

2: 93 percent / NaHCO₃ / ethyl acetate; H₂O / 0.33 h / 0 °C

With 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/ol015504w

Reference yield:

: 95107-99-6
tert-butyl (S)-(1-oxopent-4-en-2-yl)carbamate

: 335160-63-9
(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 14 h / 20 °C

2: 93 percent / NaHCO₃ / ethyl acetate; H₂O / 0.33 h / 0 °C

With 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/ol015504w