(S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester

Base Information

Chemical Name:(S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester
CAS No.:473930-84-6
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:

Synonyms:(S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester

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Chemical Property of (S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester

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Technology Process of (S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester

There total 5 articles about (S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 473930-84-6
(S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / LHMDS / hexane; tetrahydrofuran / 12 h / -78 °C

2: 76 percent Turnov_. / Et₃N / 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1016/S0957-4166(02)00224-0

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 473930-84-6
(S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NH₄Cl / methanol; H₂O / 8 h / 20 °C

1.2: HCl / methanol

1.3: 57 percent / TsOH / toluene / 24 h / Heating

2.1: 69 percent / LHMDS / hexane; tetrahydrofuran / 12 h / -78 °C

3.1: 76 percent Turnov_. / Et₃N / 20 °C

With ammonium chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; water;
DOI:10.1016/S0957-4166(02)00224-0

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 473930-84-6
(S)-2-[(R)-(2-hydroxy-1-phenylethyl)amino]-2-(4-methylphenyl)succinic acid 4-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NH₄Cl / methanol; H₂O / 8 h / 20 °C

1.2: HCl / methanol

1.3: 57 percent / TsOH / toluene / 24 h / Heating

2.1: 69 percent / LHMDS / hexane; tetrahydrofuran / 12 h / -78 °C

3.1: 76 percent Turnov_. / Et₃N / 20 °C

With ammonium chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; water;
DOI:10.1016/S0957-4166(02)00224-0