1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate
CAS No.:960122-35-4
Molecular Formula:C₃₀H₄₁FN₄O₃
Molecular Weight:524.679
Hs Code.:

Synonyms:1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

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Technology Process of 1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

There total 5 articles about 1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₈ClN₃O₃

: 4-(4-fluorophenyl)piperidine hydrochloride

: 960122-35-4
1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 960122-35-4
1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

2.1: iron; ammonium chloride / methanol; water / 2 h / 80 °C

3.1: sodium methylate / methanol / 24 h / 50 °C

3.2: 1 h / 50 °C

4.1: sodium hydrogencarbonate / dichloromethane; water; toluene / 0.33 h / 0 °C

5.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 120 °C / Microwave irradiation

With sodium methylate; sodium tris(acetoxy)borohydride; iron; sodium hydrogencarbonate; ammonium chloride; triethylamine; In methanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: 960121-90-8
1,1-dimethylethyl (2S)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylate

: 960122-35-4
1,1-dimethylethyl (2S)-4-({4-[{[4-(4-fluorophenyl)-1-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: iron; ammonium chloride / methanol; water / 2 h / 80 °C

2.1: sodium methylate / methanol / 24 h / 50 °C

2.2: 1 h / 50 °C

3.1: sodium hydrogencarbonate / dichloromethane; water; toluene / 0.33 h / 0 °C

4.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 120 °C / Microwave irradiation

With sodium methylate; iron; sodium hydrogencarbonate; ammonium chloride; triethylamine; In methanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;