[1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

Base Information

Chemical Name:[1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide
CAS No.:620140-92-3
Molecular Formula:C₂₈H₂₇NO₃S₂
Molecular Weight:489.659
Hs Code.:

Synonyms:[1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

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Chemical Property of [1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

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Technology Process of [1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

There total 3 articles about [1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 620140-01-4
[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide

: 620140-92-3
[1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

Guidance literature:: With tetrabutyl ammonium fluoride; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ol0358410

Reference yield:

: 350479-90-2
(S,E)-N-benzylidene-4-methylbenzenesulfinamide

: 620140-92-3
[1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 81 percent / tetrahydrofuran; hexane / -78 °C

2.1: 95 percent / nBu₄F / CH₂Cl₂ / 3 h / 20 °C

With tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol0358410

Reference yield:

: 302934-11-8
(S)-2-(Triisopropylsyloxymethyl)phenyl p-tolylsulfoxide

: 620140-92-3
[1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 81 percent / tetrahydrofuran; hexane / -78 °C

2.1: 95 percent / nBu₄F / CH₂Cl₂ / 3 h / 20 °C

With tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol0358410