3-(4-(benzyloxy)phenyl)-2-cyano-N-methylacrylamide

Base Information

Chemical Name:3-(4-(benzyloxy)phenyl)-2-cyano-N-methylacrylamide
CAS No.:939644-23-2
Molecular Formula:C₁₈H₁₆N₂O₂
Molecular Weight:292.337
Hs Code.:

Synonyms:3-(4-(benzyloxy)phenyl)-2-cyano-N-methylacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-(benzyloxy)phenyl)-2-cyano-N-methylacrylamide

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Technology Process of 3-(4-(benzyloxy)phenyl)-2-cyano-N-methylacrylamide

There total 2 articles about 3-(4-(benzyloxy)phenyl)-2-cyano-N-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4397-53-9
p-benzyloxybenzaldehyde

: 6330-25-2
N-methyl-2-cyanoacetamide

: 939644-23-2
3-(4-(benzyloxy)phenyl)-2-cyano-N-methylacrylamide

Guidance literature:: With piperidine; In toluene; for 15h; Reflux;
DOI:10.3390/md10061412

Reference yield:

: 100-39-0
benzyl bromide

: 939644-23-2
3-(4-(benzyloxy)phenyl)-2-cyano-N-methylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 3 h

2: piperidine / toluene / 15 h / Reflux

With piperidine; potassium carbonate; In acetone; toluene; 2: Knoevenagel condensation;
DOI:10.3390/md10061412