3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid

Base Information

• Chemical Name: 3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid
• CAS No.: 886967-72-2
• Molecular Formula: C₁₂H₁₀F₃NO₃
• Molecular Weight: 273.212

Synonyms:3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid

Chemical Property of 3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-3-(4-(trifluoromethyl)phenyl)-4,5-dihydroisoxazole-5-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of 3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid

There total 2 articles about 3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydroisoxazole-5-carboxylate (886967-67-5) → 3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid (886967-72-2)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1002/jhet.5570430240

Reference yield:

N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride (74467-05-3) → 3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid (886967-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / triethylamine; MgSO₄ / toluene / 20 °C

2: 87 percent / aq. sodium hydroxide / aq. ethanol / Heating

With sodium hydroxide; magnesium sulfate; triethylamine; In ethanol; toluene;

DOI:10.1002/jhet.5570430240

Reference yield:

3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydoroisoxazole-5-carboxylic acid (886967-72-2) → 5-methyl-3-(4-trifluoromethyl-phenyl)-4,5-dihydro-isoxazole-5-carbonyl chloride (1026820-26-7)

Guidance literature:

With oxalyl dichloride; In benzene; for 1.5h; Heating;

DOI:10.1002/jhet.5570430240

upstream raw materials:

ethyl 3-(4-trifluoromethylphenyl)-5-methyl-4,5-dihydroisoxazole-5-carboxylate

N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride

Downstream raw materials:

5-methyl-3-(4-trifluoromethyl-phenyl)-4,5-dihydro-isoxazole-5-carbonyl chloride

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