74467-05-3

Basic information

• Product Name: (Z)-N-hydroxy-4-(trifluoroMethyl)benziMidoyl chloride
• Synonyms: (Z)-N-hydroxy-4-(trifluoroMethyl)benziMidoyl chloride;N-Hydroxy-4-(trifluoromethyl)benzimidoyl chloride
• CAS NO: 74467-05-3
• Molecular Formula: C₈H₅ClF₃NO
• Molecular Weight: 223.5796096
• Mol File: 74467-05-3.mol
• Article Data: 37

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Z)-N-hydroxy-4-(trifluoroMethyl)benziMidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-hydroxy-4-(trifluoroMethyl)benziMidoyl chloride(74467-05-3)
• EPA Substance Registry System: (Z)-N-hydroxy-4-(trifluoroMethyl)benziMidoyl chloride(74467-05-3)

Safety Data

• Hazardous Substances Data: 74467-05-3(Hazardous Substances Data)

Usage

General Description

(Z)-N-hydroxy-4-(trifluoroMethyl)benziMidoyl chloride is a chemical compound that belongs to the class of benzamide derivatives. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound possesses a trifluoromethyl group, which makes it useful for medicinal chemistry applications, as this group is known to enhance the bioactivity and metabolic stability of drug compounds. Its reactivity and ability to undergo various chemical transformations make it a versatile building block in organic synthesis. Additionally, it can act as a coupling reagent in peptide synthesis, making it a valuable tool in the production of therapeutic peptides. Overall, (Z)-N-hydroxy-4-(trifluoroMethyl)benziMidoyl chloride is a crucial component in the synthesis of various important chemical compounds with potential pharmaceutical and agricultural applications.

Upstream product

• 16939-49-4 (E)-4-(trifluoromethyl)benzaldoxime 
• 66046-34-2 4-(trifluoromethyl)benzaldehyde oxime 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Downstream Products

• 74423-19-1 3'-<(4-trifluoromethyl)phenyl>spiro-3-one 
• 128413-22-9 2-phenyl-3'-<4-(trifluoromethyl)phenyl>spiro<1H-isoindole-1,5'(4'H)-isoxazol>-3(2H)-one 
• 159693-05-7 ethyl 3-(4-trifluoromethylphenyl)isoxazole-4-carboxylate 
• 159693-08-0 (3-(4-trifluoromethylphenyl)-5-methyl)isoxazole-4-carboxylic acid ethyl ester 
• 628329-69-1 4-(3-(4-(trifluoromethyl)phenyl)isoxazol-5-yl)butan-1-ol 
• 849738-33-6 5-Pentafluoroethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid 
• 849738-38-1 5-(Chloro-difluoro-methyl)-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid 
• 883543-16-6 3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid 
• 849738-30-3 5-Difluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid 

Relevant articles and documents

Design, synthesis, anti-cancer activity and in-silico studies of some novel 4,5-dihydroisoxazole-5-carboxamide derivatives

A novel series of 4,5-dihydroisoxazole-5-carboxamide derivatives were designed, synthesized and evaluated for their anti-cancer activity against two different human cancer cell lines. Most of the synthesized compounds showed anti-cancer activity with ICs

Design and synthesis of sinomenine isoxazole derivatives via 1,3-dipolar cycloaddition reaction

A novel structure of sinomenine isoxazole derivatives is synthesised from sinomenine hydrochloride and aromatic aldehydes and requires six steps. 19 target compounds have been obtained in good yields. The sinomenine hydrochloride transforms to 4-alkynyl sinomenine, which is a key intermediate product to synthesise the target sinomenine isoxazole compounds, after a neutralisation reaction with ammonia and substitution reaction with 3-chloropropyne. Another key intermediate product is 1,3-dipole, which can be obtained from aromatic aldehyde. After treatment with hydroxylamine hydrochloride and then sodium carbonate solution, aromatic aldehyde is converted to aldehyde oxime, which reacts with N-chlorosuccinimide (NCS) to afford aryl hydroximino chloride. 1,3-Dipole is eventually formed in situ while triethylamine (TEA) in DMF is added dropwise. Then 4-alkynyl sinomenine is added to provide the sinomenine isoxazole derivative via 1,3-dipolar cycloaddition reaction as the key step. All the target compounds are characterised by melting point, 1H NMR, 13C NMR, HRMS and FT-IR spectroscopy.

Triazole alcohol derivative as well as preparation method and application thereof

The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.