1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid

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Chemical Name:1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid
CAS No.:1334606-88-0
Molecular Formula:C₂₇H₂₈F₃N₃O₃
Molecular Weight:499.533
Hs Code.:

Synonyms:1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid

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Chemical Property of 1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid

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Technology Process of 1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid

There total 7 articles about 1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22059-21-8
aminocyclopropane-1-carboxylic acid

: 1334607-97-4
2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}benzaldehyde

: 1334606-88-0
1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid

Guidance literature:: aminocyclopropane-1-carboxylic acid; 2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}benzaldehyde; With acetic acid; In ethanol; at 20 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In ethanol; at 20 ℃;

Reference yield:

: 393-37-3
5-bromo-2-fluorobenzotrifluoride

: 1334606-88-0
1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

1.2: 50 °C

2.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

2.2: -60 - 20 °C

2.3: 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

4.1: acetic acid / ethanol / 0.33 h / 20 °C

4.2: 20 °C

With potassium phosphate; n-butyllithium; potassium tert-butylate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 2357-47-3
4-Fluoro-3-trifluoromethylaniline

: 1334606-88-0
1-{[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]amino}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice; Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

2.2: 50 °C

3.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

3.2: -60 - 20 °C

3.3: 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

5.1: acetic acid / ethanol / 0.33 h / 20 °C

5.2: 20 °C

With potassium phosphate; n-butyllithium; tert.-butylnitrite; potassium tert-butylate; acetic acid; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;