6-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

Base Information

• Chemical Name: 6-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester
• CAS No.: 1246924-65-1
• Molecular Formula: C₂₅H₁₉FN₂O₄
• Molecular Weight: 430.435
• Mol file: 1246924-65-1.mol

Synonyms:6-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

Chemical Property of 6-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 6-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

There total 1 articles about 6-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-Chloronicotinic acid methyl ester (73781-91-6) + [3-(4-Fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-yl]-methanol (1240402-79-2) → 6-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (1246924-65-1)

Guidance literature:

[3-(4-Fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-yl]-methanol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

6-Chloronicotinic acid methyl ester; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 78.0%

6-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (1246924-65-1) → 6-[3-(4-Fluoro-phenyl)-5-formyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (1246924-66-2)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; water; N-benzyl-N,N,N-triethylammonium chloride; In 1,4-dioxane; at 120 ℃; for 0.25h; Microwave irradiation;

upstream raw materials:

6-Chloronicotinic acid methyl ester

[3-(4-Fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-yl]-methanol

Downstream raw materials:

6-[3-(4-Fluoro-phenyl)-5-formyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester