2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

Base Information

Chemical Name:2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester
CAS No.:107342-79-0
Molecular Formula:C₂₂H₂₂BrNO₄
Molecular Weight:444.325
Hs Code.:

Synonyms:2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

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Chemical Property of 2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

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Technology Process of 2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

There total 5 articles about 2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10572-16-4
3-(4-nitrophenoxy)propanoic acid

: 107342-79-0
2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) SOCl₂, 2.) Na₂CO₃ / 1.) DMF, toluene, 90 deg C, 1 h, 2.) AcOEt, H₂O, RT

2: 89 percent / POCl₃ / toluene / 1 h / Heating

3: 97 percent / H₂ / 5 percent Pd/C / methanol / Ambient temperature

4: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

With copper(I) oxide; thionyl chloride; hydrogen bromide; hydrogen; sodium carbonate; sodium nitrite; trichlorophosphate; palladium on activated charcoal; In methanol; toluene;
DOI:10.1021/jm00092a012

Reference yield:

: 16735-19-6
2-amino-1-phenylpropan-1-one hydrochloride

: 107342-79-0
2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) SOCl₂, 2.) Na₂CO₃ / 1.) DMF, toluene, 90 deg C, 1 h, 2.) AcOEt, H₂O, RT

2: 89 percent / POCl₃ / toluene / 1 h / Heating

3: 97 percent / H₂ / 5 percent Pd/C / methanol / Ambient temperature

4: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

With copper(I) oxide; thionyl chloride; hydrogen bromide; hydrogen; sodium carbonate; sodium nitrite; trichlorophosphate; palladium on activated charcoal; In methanol; toluene;
DOI:10.1021/jm00092a012

Reference yield:

: 107324-95-8
α-<<3-(4-nitrophenoxy)propionyl>amino>propiophenone

: 107342-79-0
2-Bromo-3-{4-[2-(4-methyl-5-phenyl-oxazol-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / POCl₃ / toluene / 1 h / Heating

2: 97 percent / H₂ / 5 percent Pd/C / methanol / Ambient temperature

3: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

With copper(I) oxide; hydrogen bromide; hydrogen; sodium nitrite; trichlorophosphate; palladium on activated charcoal; In methanol; toluene;
DOI:10.1021/jm00092a012