Technology Process of (R)-4-((R)-((2S,3R)-3-((benzyloxy)methyl)oxiran-2-yl)fluoromethyl)-2-2dimethyl-1,3-dioxolane
There total 5 articles about (R)-4-((R)-((2S,3R)-3-((benzyloxy)methyl)oxiran-2-yl)fluoromethyl)-2-2dimethyl-1,3-dioxolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2R,3S)-3-(((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)fluoromethyl)oxiran-2-yl)methanol;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
Inert atmosphere;
benzyl bromide;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1016/j.jfluchem.2013.06.003
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ω-D-camphorsulfinic acid / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / hexane; tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere
3.1: titanium(IV)isopropoxide; tert.-butylhydroperoxide; N,N-Diisopropyltryptamine / dichloromethane / 19.5 h / -25 - -20 °C / Molecular sieve; Inert atmosphere
3.2: 0.25 h / 0 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
4.2: 1 h / 0 °C / Inert atmosphere
With
tert.-butylhydroperoxide; N,N-Diisopropyltryptamine; ω-D-camphorsulfinic acid; titanium(IV)isopropoxide; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.jfluchem.2013.06.003
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / hexane; tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere
2.1: titanium(IV)isopropoxide; tert.-butylhydroperoxide; N,N-Diisopropyltryptamine / dichloromethane / 19.5 h / -25 - -20 °C / Molecular sieve; Inert atmosphere
2.2: 0.25 h / 0 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
3.2: 1 h / 0 °C / Inert atmosphere
With
tert.-butylhydroperoxide; N,N-Diisopropyltryptamine; titanium(IV)isopropoxide; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.jfluchem.2013.06.003
