(1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:(1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester
CAS No.:77053-67-9
Molecular Formula:C₁₄H₁₃F₃O₄
Molecular Weight:302.25
Hs Code.:

Synonyms:(1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Suppliers and Price of (1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

There total 2 articles about (1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 77053-53-3
α-bromo-(4-(trifluoromethyl)phenyl)acetic acid methyl ester

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 77053-67-9
(1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: With sodium methylate; In diethyl ether; for 24h; Ambient temperature;
DOI:10.1021/jm00137a002

Reference yield:

: 135325-18-7
methyl 2-(4-(trifluoromethyl)phenyl)acetate

: 77053-67-9
(1R,2S)-1-(4-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / NBS, 48percent aq. HBr / CCl₄ / Heating

2: 66 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

With N-Bromosuccinimide; hydrogen bromide; sodium methylate; In tetrachloromethane; diethyl ether;
DOI:10.1021/jm00137a002