N-BOC-1,3-DIAMINOPROPANE HYDROCHLORIDE

Base Information

• Chemical Name: N-BOC-1,3-DIAMINOPROPANE HYDROCHLORIDE
• CAS No.: 127346-48-9
• Molecular Formula: C8H18N2O2^.HCl
• Molecular Weight: 210.704
• Hs Code.: 29241990
• Mol file: 127346-48-9.mol

Synonyms:Carbamicacid, (3-aminopropyl)-, 1,1-dimethylethyl ester, monohydrochloride (9CI);N-Boc-1,3-propanediamine hydrochloride;

Chemical Property of N-BOC-1,3-DIAMINOPROPANE HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.000546mmHg at 25°C
• Melting Point: 159-161°C
• Boiling Point: 307.2 °C at 760 mmHg
• Flash Point: 139.6 °C
• PSA: 64.35000
• LogP: 2.75310
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic

Purity/Quality:

98% ^*data from raw suppliers

Boc-1,3-cis-DiaminomethylcyclohexaneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-1,3-DIAMINOPROPANE HYDROCHLORIDE

There total 4 articles about N-BOC-1,3-DIAMINOPROPANE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl N-(3-azidopropyl)carbamate (129392-84-3) → N-<(tert-Butyloxy)carbonyl>propane-1,3-diamine hydrochloride (127346-48-9)

Guidance literature:

With chloroform; hydrogen; palladium on activated charcoal; In methanol; for 1h; under 1551.4 Torr;

DOI:10.1055/s-1990-26879

Reference yield:

N-tert-butoxycarbonyl-3-aminopropanol (58885-58-8) → N-<(tert-Butyloxy)carbonyl>propane-1,3-diamine hydrochloride (127346-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / toluene / 0.08 h / 0 °C

2: NaN₃ / tetrabutylammonium bromide / toluene; H₂O / 3 h / 60 °C

3: 99 percent / H₂, CHCl₃ / Pd-C / methanol / 1 h / 1551.4 Torr

With sodium azide; chloroform; hydrogen; triethylamine; palladium on activated charcoal; tetrabutylammomium bromide; In methanol; water; toluene;

DOI:10.1055/s-1990-26879

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-<(tert-Butyloxy)carbonyl>propane-1,3-diamine hydrochloride (127346-48-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / CH₂Cl₂ / 12 h

2: triethylamine / toluene / 0.08 h / 0 °C

3: NaN₃ / tetrabutylammonium bromide / toluene; H₂O / 3 h / 60 °C

4: 99 percent / H₂, CHCl₃ / Pd-C / methanol / 1 h / 1551.4 Torr

With sodium azide; chloroform; hydrogen; triethylamine; palladium on activated charcoal; tetrabutylammomium bromide; In methanol; dichloromethane; water; toluene;

DOI:10.1055/s-1990-26879

upstream raw materials:

tert-butyl N-(3-azidopropyl)carbamate

N-tert-butoxycarbonyl-3-aminopropanol

di-tert-butyl dicarbonate

3-(tert-butoxycarbonylamino)propyl methanesulfonate

Downstream raw materials:

N-[(3-(N-tert-butoxycarbonylamino)propyl)]acridine-9-carboxamide

5-(3-[(3-tert-butoxycarbonylamino)propylcarbamoyl]-benzylaminocarboyl)-9-hydroxy-1,3-dihydropyrrolo[3,4-c]-carbazole-1,3(2H,6H)-dione

5-(3-[(3-tert-butoxycarbonylamino)propylcarbamoyl]-benzylaminocarboyl)-1,3-dihydropyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

C₂₁H₂₆N₂O₄

Refernces

• 1、 Mattingly, Phillip G.. "Mono-Protected Diamines. Nα-tert-Butoxycarbonyl α,ω-Alkanediamine Hydrochlorides from Amino alcohols.". . p. 366 - 368. Retrieved 2007/10/02.