4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole

Base Information

• Chemical Name: 4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole
• CAS No.: 182289-34-5
• Molecular Formula: C₁₃H₁₂ClF₃N₂O₂S
• Molecular Weight: 352.765
• Mol file: 182289-34-5.mol

Synonyms:4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole

Chemical Property of 4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole

There total 5 articles about 4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3-hydroxy-1-methyl-5-methylthiopyrazole (92607-63-1) → 4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole (182289-34-5)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / methanol / Ambient temperature

2: KHCO₃ / Heating

3: aq. AcOH, Fe / 0.5 h / 80 °C

4: 41 percent / t-BuONO / dimethylformamide / Heating

With tert.-butylnitrite; iron; potassium carbonate; potassium hydrogencarbonate; acetic acid; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jf9601978

Reference yield:

2,4-difluoro-5-nitro-benzoic acid (153775-33-8) → 4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole (182289-34-5)

Guidance literature:

Multi-step reaction with 5 steps

1: HF, SF₄

2: K₂CO₃ / methanol / Ambient temperature

3: KHCO₃ / Heating

4: aq. AcOH, Fe / 0.5 h / 80 °C

5: 41 percent / t-BuONO / dimethylformamide / Heating

With tert.-butylnitrite; sulfur tetrafluoride; hydrogen fluoride; iron; potassium carbonate; potassium hydrogencarbonate; acetic acid; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jf9601978

Reference yield:

4-Chloro-3-(5-fluoro-2-nitro-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole → 4-Chloro-3-(3-methoxy-4-trifluoromethyl-phenoxy)-1-methyl-5-methylsulfanyl-1H-pyrazole (182289-34-5)

Guidance literature:

Multi-step reaction with 3 steps

1: KHCO₃ / Heating

2: aq. AcOH, Fe / 0.5 h / 80 °C

3: 41 percent / t-BuONO / dimethylformamide / Heating

With tert.-butylnitrite; iron; potassium hydrogencarbonate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jf9601978

upstream raw materials:

4-chloro-3-hydroxy-1-methyl-5-methylthiopyrazole

2,4-difluoro-5-nitro-benzoic acid

2,4-difluoro-benzoic acid