Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

Base Information

Chemical Name:Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester
CAS No.:869110-67-8
Molecular Formula:C₆₈H₁₂₁N₂O₁₆P
Molecular Weight:1253.69
Hs Code.:

Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

Synonyms:Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

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Chemical Property of Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

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Technology Process of Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

There total 7 articles about Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 869110-66-7
Hexadecanoic acid (R)-2-(benzyloxy-{4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

: 869110-67-8
Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4.5h;
DOI:10.1039/b507917a

Reference yield:

: 155163-73-8
3-(4-benzyloxyphenyl)propane-1,2-diamine

: 869110-67-8
Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2.2 g / NaI; proton sponge / acetonitrile / 13 h / Heating

2: 78 percent / H₂ / Pd/C / methanol / 2 h / 20 °C

3: 64 percent / 1H-tetrazole / CH₂Cl₂ / 2 h / 20 °C

4: 84 percent / MCPBA; NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

5: 83 percent / H₂ / Pd/C / methanol / 4.5 h / 20 °C

With 1H-tetrazole; Proton Sponge; hydrogen; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1039/b507917a

Reference yield:

: 869110-69-0
{[1-(4-benzyloxy-benzyl)-2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester

: 869110-67-8
Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / H₂ / Pd/C / methanol / 2 h / 20 °C

2: 64 percent / 1H-tetrazole / CH₂Cl₂ / 2 h / 20 °C

3: 84 percent / MCPBA; NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

4: 83 percent / H₂ / Pd/C / methanol / 4.5 h / 20 °C

With 1H-tetrazole; hydrogen; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1039/b507917a