methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate

Base Information

Chemical Name:methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate
CAS No.:1417456-50-8
Molecular Formula:C₁₅H₁₇ClN₂O₃S
Molecular Weight:340.831
Hs Code.:

Synonyms:methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate

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Chemical Property of methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate

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Technology Process of methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate

There total 3 articles about methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7
methacrylic acid methyl ester

: 53377-25-6
3-(4-chlorophenyl)-2-thioxotetrahydropyrimidin-4(1H)-one

: 1417456-50-8
methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1055/S-0032-1317133

Reference yield:

: 3744-12-5
1-(2-carboxyethyl) 3-p-chlorophenylthiouree

: 1417456-50-8
methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole / acetonitrile / 0.17 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With potassium carbonate; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/S-0032-1317133

Reference yield:

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1417456-50-8
methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 1.6 h / 20 °C

2: 1,1'-carbonyldiimidazole / acetonitrile / 0.17 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/S-0032-1317133