(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester

Base Information

Chemical Name:(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester
CAS No.:640722-90-3
Molecular Formula:C₂₉H₂₈N₂O₆
Molecular Weight:500.551
Hs Code.:

Synonyms:(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester

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Chemical Property of (S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester

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Technology Process of (S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester

There total 2 articles about (S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 640722-89-0
(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-hydroxy-butyric acid benzyl ester

: 640722-90-3
(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1021/jo0302657

Reference yield:

: 35661-38-2,35661-39-3,79990-15-1,136132-75-7
N-(9-fluorenylmethoxycarbonyl)-D-alanine

: 640722-90-3
(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBt*H₂O; HBTU / dimethylformamide / 0.17 h

1.2: 85 percent / DIEA / dimethylformamide / 8 h / 25 °C

2.1: 80 percent / Des-Martin periodinane / CH₂Cl₂ / 1 h / 25 °C

With benzotriazol-1-ol; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0302657

Reference yield: 84.0%

: 640722-90-3
(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-oxo-butyric acid benzyl ester

: 640722-83-4
2-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

Guidance literature:: With trifluoromethanesulfonic acid anhydride; Triphenylphosphine oxide; In dichloromethane; at -20 ℃; for 2h;
DOI:10.1021/jo0302657