N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide

Base Information

Chemical Name:N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide
CAS No.:1433608-20-8
Molecular Formula:C₂₂H₂₆F₂N₂O₅S
Molecular Weight:468.522
Hs Code.:

Synonyms:N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide

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Chemical Property of N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide

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Technology Process of N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide

There total 2 articles about N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69843-08-9
1-methoxy-4-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1433608-20-8
N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 7 h / 0 °C / Inert atmosphere

2: pyridine / 2.5 h / 20 °C / Inert atmosphere

With pyridine; sodium hydride; In tetrahydrofuran;
DOI:10.1002/anie.201206946

Reference yield:

: 1433607-86-3
C₁₅H₂₀F₂N₂O₃

: 98-59-9
p-toluenesulfonyl chloride

: 1433608-20-8
N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide

Guidance literature:: With pyridine; at 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1002/anie.201206946

Reference yield: 85.0%

: 1433608-20-8
N’-[3,3-difluoro-2-(p-methoxyphenyl)prop-2-en-1-yl]-N’-tert-butoxycarbonyl-p-toluenesulfonohydrazide

: 1433608-74-2
tert-butyl 3-fluoro-4-(p-methoxyphenyl)-1H-pyrazole-1-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 72h; regioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201206946