69843-08-9

Basic information

• Product Name: Benzene, 1-methoxy-4-[1-(trifluoromethyl)ethenyl]-
• CAS NO: 69843-08-9
• Molecular Formula: C10H9F3O
• Molecular Weight: 202.176
• Mol File: 69843-08-9.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-[1-(trifluoromethyl)ethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-[1-(trifluoromethyl)ethenyl]-(69843-08-9)
• EPA Substance Registry System: Benzene, 1-methoxy-4-[1-(trifluoromethyl)ethenyl]-(69843-08-9)

Safety Data

• Hazardous Substances Data: 69843-08-9(Hazardous Substances Data)

Upstream product

• 711-38-6 4'-methoxy-2,2,2-trifluoroacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 637036-90-9 (±)-trimethyl({[1,1,1-trifluoro-2-(4-methoxyphenyl)propan-2-yl]oxy})silane 
• 69843-10-3 1-chloro-4-(1,1,1-trifluoroprop-2-en-2-yl)benzene 
• 536-74-3 phenylacetylene 
• 696-62-8 para-iodoanisole 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 2730-62-3 2-chloro-1,1,1-trifluoropropene 
• 124-63-0 methanesulfonyl chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 357274-85-2 α-(trifluoromethyl)ethenyl boronic acid 
• 1541177-41-6 1,1,1-trifluoro-2-(4-methoxyphenyl)-3-(trimethylsilyl)propan-2-ol 

Downstream Products

• 1079398-12-1 1-(1,1-difluoro-3-phenylprop-1-en-2-yl)-4-methoxybenzene 
• 1541177-63-2 3,3,3-trifluoro-2-(4-methoxyphenyl)propane-1,2-diol 
• 1541177-61-0 1-(1-bromo-3,3,3-trifluoroprop-1-en-2-yl)-4-methoxybenzene 
• 1541177-64-3 1-(1-bromo-3,3,3-trifluoroprop-1-en-2-yl)-4-methoxybenzene 
• 1431983-72-0 1-(2,2-difluoro-1-(trifluoromethyl)cyclopropyl)-4-methoxybenzene 
• 1541177-62-1 1-(3,3-difluoro-2-(4-methoxyphenyl)allyl)piperidine 
• 1638968-66-7 (3-fluoro-4-(4-methoxyphenyl)cyclopenta-1,3-diene-1,2-diyl)dibenzene 

Relevant articles and documents

Electroreductive Cross-Coupling of Trifluoromethyl Alkenes and Redox Active Esters for the Synthesis of Gem-Difluoroalkenes

An electroreductive access to gem-difluoroalkenes has been developed through the decarboxylative/defluorinative coupling of N-hydroxyphtalimides esters and α-trifluoromethyl alkenes. The electrolysis is performed under very simple reaction conditions in a

A Chiral Pentafluorinated Isopropyl Group via Iodine(I)/(III) Catalysis

An I(I)/(III) catalysis strategy to construct an enantioenriched fluorinated isostere of the iPr group is reported. The difluorination of readily accessible α-CF3-styrenes is enabled by the in situ generation of a chiral ArIF2 species to forge a stereocentre with the substituents F, CH2F and CF3 (up to 95 %, >20:1 vicinal:geminal difluorination). The replacement of the metabolically labile benzylic proton results in a highly preorganised scaffold as was determined by X-ray crystallography (π→σ* and stereoelectronic gauche σ→σ* interactions). A process of catalyst editing is disclosed in which preliminary validation of enantioselectivity is placed on a structural foundation.

One-pot synthesis of α-trifluoromethylstyrenes from aryl ketones and the Ruppert–Prakash reagent

A new synthesis of α-trifluoromethylstyrenes from aromatic ketones and (trifluoromethyl) trimethylsilane is described. The reaction involves nucleophilic trifluoromethylation and elimination of trimethylsilanol, which are performed within one reaction fla

Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

The site-selective functionalization of unactivated aliphatic amines is an attractive and challenging synthetic approach. We herein report a general strategy for the remote site-selective functionalization of unactivated C(sp3)-H bonds in amides by photogenerated amidyl radicals to form gem-difluoroalkenes with trifluoromethyl-substituted alkenes. The site selectivity is controlled by a 1,5-hydrogen atom transfer (HAT) process of the amide. This photocatalyzed transformation shows both chemo- and site-selectivity, facilitating the formation of a secondary, tertiary, or quaternary carbon center.

Photoredox/Hydrogen Atom Transfer Cocatalyzed C-H Difluoroallylation of Amides, Ethers, and Alkyl Aldehydes

Herein, we report a method that combines hydrogen atom transfer and photoredox catalysis to achieve the dehydrogenative difluoroallylation of amides, ethers, and alkyl aldehydes. This operationally convenient method transforms a broad scope of substrates into the corresponding gem-difluoroalkenes via the construction of C(sp3)-C(sp3) or C(sp3)-C(sp2) bonds. Excellent functional group compatibility and high selectivity make this method have a wide range of substrate types and render it suitable for late-stage modification of pharmaceutical intermediates.

Photoredox relay-catalyzedgem-difluoroallylation of alkyl iodides

Herein, a new example of relay catalysis, using a combination of Mn2(CO)10and an iridium-based photocatalyst, is reported. In our relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction conditions, and do not inhibit each other. This convenient method transforms a broad scope of alkyl iodides into the correspondinggem-difluoroalkenesviaC(sp3)-C(sp3) bond construction. The protocol has good functional group tolerance and is suitable for the late-stage modification of multifunctional complex molecules.

Site-Selective Defluorinative sp3C-H Alkylation of Secondary Amides

A site-selective defluorinative sp3 C-H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp3 sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.

Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol

Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant molecules. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy.

Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols

An unprecedented electrochemical heterodifunctionalization of α-CF3alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.

Glycosyl-Radical-Based Synthesis of C-Alkyl Glycosides via Photomediated Defluorinative gem-Difluoroallylation

We have developed a stereoselective, glycosyl radical-based method for the synthesis of C-alkyl glycosides via a photomediated defluorinative gem-difluoroallylation reaction. We demonstrate for the first time that glycosyl radicals, generated from glycosyl bromides, can readily participate in a photomediated radical polar crossover process, affording a diverse array of gem-difluoroalkene containing C-glycosides. Notable features of this method include scalability, mild conditions, broad substrate scope, and suitability for the late-stage modification of complex molecules.