2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

Base Information

• Chemical Name: 2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide
• CAS No.: 394235-31-5
• Molecular Formula: C₂₁H₁₉N₅O₄S₂
• Molecular Weight: 469.545

Synonyms:2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

Chemical Property of 2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

Chemical Property:

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Technology Process of 2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

There total 2 articles about 2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-cyano-3,3-bis(methylthio)-N-phenylacrylamide (17917-51-0) + N'-(2-cyanoacetyl)-4-methylbenzenesulfonohydrazide (99056-41-4) → 2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide (394235-31-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 5h; Heating;

DOI:10.1080/10426500108040593

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide (394235-31-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / ethanol / 24 h / 20 °C

2: 75 percent / K₂CO₃ / dimethylformamide / 5 h / Heating

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1080/10426500108040593

Reference yield: 75.0%

2-amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid phenylamide (394235-31-5) → 3,6-diamino-4-oxo-5-(toluene-4-sulfonylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridine-7-carboxylic acid phenylamide

Guidance literature:

With piperidine; hydrazine hydrate; In N,N-dimethyl-formamide; for 4h; Heating;

DOI:10.1080/10426500108040593

upstream raw materials:

2-cyano-3,3-bis(methylthio)-N-phenylacrylamide

N'-(2-cyanoacetyl)-4-methylbenzenesulfonohydrazide

p-toluenesulfonyl chloride

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