(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine

Base Information

Chemical Name:(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine
CAS No.:642442-08-8
Molecular Formula:C₂₅H₂₆N₂
Molecular Weight:354.495
Hs Code.:

Synonyms:(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine

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Chemical Property of (14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine

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Technology Process of (14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine

There total 2 articles about (14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 642442-06-6
(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,10,14b-tetrahydrodibenzo[c,f]pyrazino[1,2-a]azepine-3,4-dione

: 642442-08-8
(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine

Guidance literature:: (14bR)-2-[(1'S)-1'-phenylethyl]-1,2,10,14b-tetrahydrodibenzo[c,f]pyrazino[1,2-a]azepine-3,4-dione; With dimethylsulfide borane complex; In tetrahydrofuran; for 4h; Heating;

With hydrogenchloride; In water; for 2h; Heating;
DOI:10.1016/S0957-4166(03)00582-2

Reference yield:

: N-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)-N-[(1'S)-1'-phenylethyl]amine

: 642442-08-8
(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / CH₂Cl₂ / 24 h / -78 °C

2.1: Me₂S*BH₃ / tetrahydrofuran / 4 h / Heating

2.2: 94 percent / HCl / H₂O / 2 h / Heating

With pyridine; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(03)00582-2

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 642442-08-8
(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine

: 51152-88-6
(S)-(+)-mianserin

: 78684-63-6
(-)-Mianserin

Guidance literature:: (14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine; With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; for 3h; atmospheric pressure;

formaldehyd; In ethanol; water; at 10 ℃;

With sodium tetrahydroborate; In ethanol; water; Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(03)00582-2