2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide

Base Information

Chemical Name:2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide
CAS No.:182115-82-8
Molecular Formula:C₂₇H₃₄N₂O₃
Molecular Weight:434.579
Hs Code.:

Synonyms:2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide

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Chemical Property of 2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide

Chemical Property:

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Technology Process of 2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide

There total 8 articles about 2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177557-32-3
2-(8-benzyloxy-3-(3,5-di-t-butylbenzyl-2-ethylindolizin-1-yl))glyoxylamide

: 182115-82-8
2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm960395q

Reference yield:

: 1121-25-1,55780-69-3
2-methyl-3-pyridinol

: 182115-82-8
2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / KOH, tetrabutylammonium bromide / tetrahydrofuran / 1.5 h / Ambient temperature

2: 90.1 percent / ethyl acetate / 0.5 h / 70 °C

3: 79 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

4: 82 percent / benzene / 4 h / Heating

5: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

6: tetrahydrofuran / 0 °C

7: aq. NH₄OH / tetrahydrofuran / Ambient temperature

8: H₂ / 10percent Pd/C / ethyl acetate

With potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; tetrabutylammomium bromide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 177559-01-2
3-(benzyloxy)-2-methylpyridine

: 182115-82-8
2-[3-(3,5-Di-tert-butyl-benzyl)-2-ethyl-8-hydroxy-indolizin-1-yl]-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 90.1 percent / ethyl acetate / 0.5 h / 70 °C

2: 79 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

3: 82 percent / benzene / 4 h / Heating

4: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

5: tetrahydrofuran / 0 °C

6: aq. NH₄OH / tetrahydrofuran / Ambient temperature

7: H₂ / 10percent Pd/C / ethyl acetate

With ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm960395q