N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide

Base Information

Chemical Name:N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide
CAS No.:178870-85-4
Molecular Formula:C₂₉H₄₀ClNO₃SSi
Molecular Weight:546.246
Hs Code.:

Synonyms:N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide

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Chemical Property of N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide

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Technology Process of N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide

There total 4 articles about N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 178870-79-6
1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-methyl)ethylazulene

: 178870-85-4
N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1016/0968-0896(96)00038-7

Reference yield:

: 178870-61-6
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(1-hydroxy-1-methyl-ethyl)-azulene-1-carboxylic acid methyl ester

: 178870-85-4
N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / p-TsOH / benzene / 0.33 h / Heating

2: 1.) BH₃*THF, 2.) 6N aq. NaOH, 30percent aq. H₂O₂ / 1.) 0 deg C, 3 h, 2.) RT, 1 h

3: 77 percent / 100percent phosphoric acid / 0.17 h / 110 °C

4: 97 percent / Et₃N / dimethylformamide / 2 h / Ambient temperature

With sodium hydroxide; borane-THF; phosphoric acid; dihydrogen peroxide; toluene-4-sulfonic acid; triethylamine; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/0968-0896(96)00038-7

Reference yield:

: 178870-67-2
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-isopropenyl-azulene-1-carboxylic acid methyl ester

: 178870-85-4
N-(4-{6-[2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-azulen-1-yl}-butyl)-4-chloro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BH₃*THF, 2.) 6N aq. NaOH, 30percent aq. H₂O₂ / 1.) 0 deg C, 3 h, 2.) RT, 1 h

2: 77 percent / 100percent phosphoric acid / 0.17 h / 110 °C

3: 97 percent / Et₃N / dimethylformamide / 2 h / Ambient temperature

With sodium hydroxide; borane-THF; phosphoric acid; dihydrogen peroxide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/0968-0896(96)00038-7