4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid

Base Information

Chemical Name:4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid
CAS No.:948833-41-8
Molecular Formula:C₂₂H₂₅ClN₂O₄S
Molecular Weight:448.971
Hs Code.:

Synonyms:4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid

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Chemical Property of 4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid

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Technology Process of 4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid

There total 3 articles about 4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid isopropyl ester

: 948833-41-8
4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid

Guidance literature:: 4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid isopropyl ester; With methanol; lithium hydroxide; water; at 20 ℃; Heating / reflux;

With water; acetic acid; In methanol;

Reference yield:

: 948833-62-3
4-fluoro-2-hydroxy-benzoic acid isopropyl ester

: 948833-41-8
4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; sodium methylate

1.2: 0.17 h / 100 °C / Microwave irradiation

2.1: methanol; lithium hydroxide; water / 20 °C / Heating / reflux

With methanol; lithium hydroxide; water; sodium methylate;

Reference yield:

: 345-29-9
4-fluorosalicylic acid

: 948833-41-8
4-{[1-(4-chloro-3-methyl-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-2-hydroxy-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 17 h / Heating / reflux

2.1: methanol; sodium methylate

2.2: 0.17 h / 100 °C / Microwave irradiation

3.1: methanol; lithium hydroxide; water / 20 °C / Heating / reflux

With methanol; lithium hydroxide; thionyl chloride; water; sodium methylate;