345-29-9

Basic information

• Product Name: 4-FLUORO-2-HYDROXYBENZOIC ACID
• Synonyms: fluorohydroxybenzoicacid5;RARECHEM AL BE 1428;4-FLUORO-2-HYDROXYBENZOIC ACID;4-FLUOROSALICYCLIC ACID;4-FLUOROSALICYLIC ACID;2-HYDROXY-4-FLUOROBENZOIC ACID;4-Fluoro-2-Hydroxybenzoic Acid 2-Hydroxy-4-Fluoro Benzoic Acid;4-Fluorosalicylicacid,98%
• CAS NO: 345-29-9
• Molecular Formula: C₇H₅FO₃
• Molecular Weight: 156.11
• EINECS: 206-459-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Acids & Esters;Fluorine Compounds;Phenols;C7;Carbonyl Compounds;Carboxylic Acids;Fluorine series
• Mol File: 345-29-9.mol
• Article Data: 16

Chemical Properties

• Melting Point: 170 °C (dec.)(lit.)
• Boiling Point: 300.5 °C at 760 mmHg
• Flash Point: 135.6 °C
• Appearance: White to orange/Crystalline Powder
• Density: 1.492 g/cm³
• Refractive Index: 1.513
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Soluble in methanol.
• PKA: 2.85±0.10(Predicted)
• BRN: 2209124
• CAS DataBase Reference: 4-FLUORO-2-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2-HYDROXYBENZOIC ACID(345-29-9)
• EPA Substance Registry System: 4-FLUORO-2-HYDROXYBENZOIC ACID(345-29-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 345-29-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

4-Fluorosalicylic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

General Description

4-Fluorosalicylic acid can be synthesized from the following compounds:4-fluorotoluenem-fluorophenol4-aminosalicylic acid

InChI:InChI=1/C9H4F3NO2/c10-9(11,12)4-1-2-6-5(3-4)7(14)8(15)13-6/h1-3H,(H,13,14,15)

Upstream product

• 392-04-1 methyl 4-fluoro-2-hydroxybenzoate 
• 138469-95-1 (E)-3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)prop-2-en-1-one 
• 201230-82-2 carbon monoxide 
• 372-20-3 3-fluorophenol 
• 7647-01-0 hydrogenchloride 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 65-49-6 4-Aminosalicylic acid 
• 56096-89-0 4-fluoro-2-iodobenzoic acid 
• 395-82-4 4-fluoro-2-methoxy-benzoic acid 
• 1377585-19-7 N-[2-acetoxy-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine 
• 456-22-4 4-Fluorobenzoic acid 
• 446-32-2 4-fluoroanthranilic acid 
• 450-83-9 4-fluoro-2-methoxybenzaldehyde 
• 348-28-7 4-fluoro-2-hydroxybenzaldehyde 

Downstream Products

• 314298-06-1 [5-fluoro-2-(3-nitro-benzylcarbamoyl)-phenoxy]-acetic acid ethyl ester 
• 314298-07-2 [5-fluoro-2-(3-nitro-benzylthiocarbamoyl)-phenoxy]-acetic acid ethyl ester 
• 314298-37-8 4-fluoro-2-hydroxy-N-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-benzamide 
• 314298-39-0 {5-fluoro-2-[(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-thiocarbamoyl]-phenoxy}-acetic acid ethyl ester 
• 314298-38-9 {5-fluoro-2-[(4,5,7-trifluoro-benzothiazol-2-ylmethyl)carbamoyl]-phenoxy}-acetic acid ethyl ester 
• 392-04-1 methyl 4-fluoro-2-hydroxybenzoate 
• 189283-52-1 5-chloro-4-fluoro-2-hydroxybenzoic acid 
• 948833-62-3 4-fluoro-2-hydroxy-benzoic acid isopropyl ester 

Relevant articles and documents

Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids

A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.

A Bcl - 2 inhibitor venetoclax and intermediate preparation method (by machine translation)

The invention relates to a process for preparing Bcl - 2 inhibitor venetoclax required intermediate preparation method, a synthetic route thereof are shown below, in particular comprises the following steps: to compound I 2, 4 - difluoro-benzoic acid as the raw material, and after hydroxy methyl esterification reaction to obtain compound II 4 - fluorosalicylic acid methyl ester, compound II with the piperazine coupling to make the compound III, compound III and IV by the reaction of the raw material compound V, the compound V with compound VI 5 - bromo - 7 - aza indole C - O prepared by coupling compound VII, is intermediate. Preparation method of this invention mild reaction conditions, the operation is simple, environmental protection and high-efficiency and low cost, easy to manufacture on a large scale. (by machine translation)

Sulfoximines: A reusable directing group for chemo-and regioselective ortho C-H oxidation of arenes

Sulfoximines direct: A new protocol for the chemo-and regioselective ortho C-H acetoxylation of arenes in N-benzoylated sulfoximines is reported. The sulfoximine directing group is easily detached from the C-H oxidation product through acid-promoted hydrolysis, isolated, and reused (see scheme). The meta-substituted phenols are synthesized following this strategy and the stereointegrity of the sulfoximine is preserved in this transformation. C(sp3)-H acetoxylation of the methyl group is also demonstrated.