8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

Base Information

Chemical Name:8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride
CAS No.:1443540-09-7
Molecular Formula:C₃₀H₃₁NO₄P*Cl
Molecular Weight:536.007
Hs Code.:

Synonyms:8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

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Chemical Property of 8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

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Technology Process of 8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

There total 10 articles about 8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1443540-07-5
5-(chloromethyl)-3,3,9,9-tetramethyl-7,11-dihydro-1H-[1,3]dioxepino[5,6-b][1,3]dioxino[5,4-d]pyridine

: 603-35-0
triphenylphosphine

: 1443540-09-7
8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

Guidance literature:: In acetonitrile; for 7h; Reflux;
DOI:10.1016/j.bmc.2013.04.051

Reference yield:

: 58-56-0
pyridoxal hydrochloride

: 1443540-09-7
8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride / 3 h / 20 °C

2: sodium hydroxide / water / 60 h / 70 °C

3: hydrogenchloride / 20 h / 20 °C

4: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h / 20 °C

5: 4 h / 100 °C

6: sodium methylate / chloroform; methanol

7: methanesulfonyl chloride / chloroform / 5 h / Reflux

8: acetonitrile / 7 h / Reflux

With hydrogenchloride; sodium methylate; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In methanol; chloroform; water; acetonitrile;
DOI:10.1016/j.bmc.2013.04.051

Reference yield:

: 1207071-01-9
6-(hydroxymethyl)-3,3,8-trimethyl-1,5-dihydro-[1,3] dioxepino [5,6-c] pyridin-9-ol

: 1443540-09-7
8-[(triphenylphosphonio)methyl]-5,6-bis(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; 2,2-dimethoxy-propane / 30 h / 20 °C

2: hydrogenchloride / 20 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h / 20 °C

4: 4 h / 100 °C

5: sodium methylate / chloroform; methanol

6: methanesulfonyl chloride / chloroform / 5 h / Reflux

7: acetonitrile / 7 h / Reflux

With hydrogenchloride; sodium methylate; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; 2,2-dimethoxy-propane; In methanol; chloroform; acetonitrile;
DOI:10.1016/j.bmc.2013.04.051