2-O-benzyl-3,5-O-(di-tert-butylsilanediyl)-α-L-arabinifuranosyl trichloroacetimidate

Base Information

• Chemical Name: 2-O-benzyl-3,5-O-(di-tert-butylsilanediyl)-α-L-arabinifuranosyl trichloroacetimidate
• CAS No.: 952575-74-5
• Molecular Formula: C₂₂H₃₂Cl₃NO₅Si
• Molecular Weight: 524.944
• Mol file: 952575-74-5.mol

Synonyms:2-O-benzyl-3,5-O-(di-tert-butylsilanediyl)-α-L-arabinifuranosyl trichloroacetimidate

Chemical Property of 2-O-benzyl-3,5-O-(di-tert-butylsilanediyl)-α-L-arabinifuranosyl trichloroacetimidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-O-benzyl-3,5-O-(di-tert-butylsilanediyl)-α-L-arabinifuranosyl trichloroacetimidate

There total 1 articles about 2-O-benzyl-3,5-O-(di-tert-butylsilanediyl)-α-L-arabinifuranosyl trichloroacetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C20H32O5Si + trichloroacetonitrile (545-06-2) → 2-O-benzyl-3,5-O-(di-tert-butylsilanediyl)-α-L-arabinifuranosyl trichloroacetimidate (952575-74-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/anie.200701750

Reference yield: 84.0%

2-O-benzyl-3,5-O-(di-tert-butylsilanediyl)-α-L-arabinifuranosyl trichloroacetimidate (952575-74-5) + phenyl 2,4-di-O-benzoyl-1-thio-α-L-rhamnopyranoside (145836-07-3) → phenyl 2-O-benzyl-3,5-O-(di-tert-butylsilane-diyl)-β-L-arabinofuranosyl-(1->3)-2,4-di-O-benzoyl-1-thio-α-L-rhamnopyranoside (952575-81-4)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In dichloromethane; at -70 - -10 ℃; for 1.5h;

DOI:10.1002/anie.200701750

upstream raw materials:

trichloroacetonitrile

Downstream raw materials:

phenyl 2-O-benzyl-3,5-O-(di-tert-butylsilane-diyl)-β-L-arabinofuranosyl-(1->3)-2,4-di-O-benzoyl-1-thio-α-L-rhamnopyranoside