6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine

Base Information

Chemical Name:6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine
CAS No.:156420-36-9
Molecular Formula:C₃₂H₂₉ClN₄O₇S
Molecular Weight:649.124
Hs Code.:

Synonyms:6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine

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Technology Process of 6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine

There total 6 articles about 6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 124-63-0
methanesulfonyl chloride

: 156420-35-8
6-chloro-9-(2-O-acetyl-5-O-trityl-β-D-arabinofuranosyl)purine

: 156420-36-9
6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine

Guidance literature:: In pyridine; for 3h; Ambient temperature;
DOI:10.1080/15257779408013260

Reference yield:

: 2004-06-0
6-Chloropurine riboside

: 156420-36-9
6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine

Guidance literature:: Multi-step reaction with 6 steps

1: 69 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 69 percent / 4-dimethylaminopyridine, triethylamine / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 78 percent / dimethylformamide / Ambient temperature

4: 60 percent / tetrabutylammonium fluoride, acetic acid / tetrahydrofuran / 0.17 h / 0 °C

5: 61 percent / pyridine / Ambient temperature

6: 79 percent / pyridine / 3 h / Ambient temperature

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408013260

Reference yield:

: 103285-18-3
(6aR,8R,9R,9aS)-8-(6-chloro-9H-purin-9-yl)-2,2,4,4-tetraisopropyl tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-ol

: 156420-36-9
6-chloro-9-(2-O-acetyl-3-O-mesyl-5-O-trityl-β-D-arabinofuranosyl)purine

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / 4-dimethylaminopyridine, triethylamine / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 78 percent / dimethylformamide / Ambient temperature

3: 60 percent / tetrabutylammonium fluoride, acetic acid / tetrahydrofuran / 0.17 h / 0 °C

4: 61 percent / pyridine / Ambient temperature

5: 79 percent / pyridine / 3 h / Ambient temperature

With dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408013260