4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

Base Information

Chemical Name:4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one
CAS No.:916907-17-0
Molecular Formula:C₂₇H₂₈ClN₇O₂
Molecular Weight:518.018
Hs Code.:

Synonyms:4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

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Chemical Property of 4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

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Technology Process of 4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

There total 5 articles about 4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 916907-15-8
4-(2-chloro-5-methoxyphenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

: 16153-81-4
4-(4-Methyl-piperazino)-anilin

: 916907-17-0
4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

Guidance literature:: at 140 ℃; for 2h;
DOI:10.3987/com-06-10806

Reference yield:

: 61044-96-0
4-chloro-5-methyl-2-(methylsulfanyl)pyrimidine

: 916907-17-0
4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / N-bromosuccinimide / benzoyl peroxide / 1,2-dichloro-ethane / 2 h / Heating

2: 21 percent / LDA / tetrahydrofuran / -78 °C

3: 95 percent / N,N-diisopropylethylamine / dimethylformamide / 80 °C

4: 79 percent / p-TsOH; molecular sieves / toluene / 130 °C

5: 22 percent / 2 h / 140 °C

With N-Bromosuccinimide; molecular sieve; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; dibenzoyl peroxide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.3987/com-06-10806

Reference yield:

: 909095-74-5
5-bromomethyl-4-chloro-2-(methylthio)pyrimidine

: 916907-17-0
4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 21 percent / LDA / tetrahydrofuran / -78 °C

2: 95 percent / N,N-diisopropylethylamine / dimethylformamide / 80 °C

3: 79 percent / p-TsOH; molecular sieves / toluene / 130 °C

4: 22 percent / 2 h / 140 °C

With molecular sieve; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.3987/com-06-10806