61044-96-0

Basic information

• Product Name: 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE
• Synonyms: 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE;4-chloro-5-methyl-2-(methylthio)pyrimidine
• CAS NO: 61044-96-0
• Molecular Formula: C₆H₇ClN₂S
• Molecular Weight: 174.65118
• EINECS: 604-604-1
• Mol File: 61044-96-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 35℃
• Boiling Point: 263℃
• Flash Point: 113℃
• Appearance: /
• Density: 1.30
• Vapor Pressure: 0.0177mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -0.16±0.29(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE(61044-96-0)
• EPA Substance Registry System: 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE(61044-96-0)

Safety Data

• Hazardous Substances Data: 61044-96-0(Hazardous Substances Data)

Usage

Uses

4-Chloro-5-methyl-2-(methylthio)pyrimidine is a useful reactant in the preparation of 1,?2-?dihydropyrimido[4,?5-?c]?pyridazine based inhibitor for lymphocyte specific kinase (Lck).

InChI:InChI=1/C6H7ClN2S/c1-4-3-8-6(10-2)9-5(4)7/h3H,1-2H3

Upstream product

• 20651-30-3 2-methylthio-3,4-dihydro-5-methylpyrimidin-4-one 
• 20651-30-3 5-methyl-2-(methylthio)pyrimidin-4-ol 
• 636-26-0 5-methyl-2-thiouracil 

Downstream Products

• 54308-64-4 5-methyl-2-methylthiopyrimidin-4-amine 
• 916906-99-5 2-(4-chloro-2-(methylthio)pyrimidin-5-yl)-1-(2-chlorophenyl)ethanone 
• 325780-94-7 4-chloro-5-methyl-2-(methylsulfonyl)pyrimidine 
• 916907-01-2 (3-(2-chlorophenyl)-1,2-dimethyl-7-(methanesulfinyl)-1,2-dihydropyrimido[4,5-c]pyridazine) 
• 916907-00-1 3-(2-chlorophenyl)-1,2-dimethyl-7-(methylthio)-1,2-dihydropyrimido[4,5-c]pyridazine 
• 916907-17-0 4-(2-chloro-5-methoxyphenyl)-8-[4-(4-methylpiperazin-1-yl)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one 
• 916907-15-8 4-(2-chloro-5-methoxyphenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one 
• 916907-14-7 1-{5-[2-(2-chloro-5-methoxyphenyl)-2-oxoethyl]-2-methylsulfanylpyrimidin-4-yl}pyrazolidin-3-one 
• 916907-13-6 1-(2-chloro-5-methoxyphenyl)-2-(4-chloro-2-methylsulfanylpyrimidin-5-yl)ethanone 
• 909095-82-5 4-(2,6-dichlorophenyl)-8-methylsulfinyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one 
• 916907-11-4 4-(2,6-dichlorophenyl)-4-hydroxy-8-methylsulfanyl-1,2,4,5-tetrahydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one 
• 909095-78-9 1-{5-[2-(2,6-dichlorophenyl)-3-oxoethyl]-2-methylsulfanylpyrimidin-4-yl}pyrazolidin-3-one 
• 909095-79-0 4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one 
• 909095-76-7 1-(2,6-dichloro-phenyl)-2-[4-(N,N'-dimethyl-hydrazino)-2-methylsulfanyl-pyrimidin-5-yl]-ethanone 

Relevant articles and documents

SELECTIVE INHIBITORS AGAINST Cdk4 AND Cdk6 HAVING AMINOTHIAZOLE SKELETON

The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH 2 ; Y 1 , Y 2 , Y 3 , Y 4 and Y 5 , which may be identical or different, are each CH or N; however, at least one of Y 1 , Y 2 , Y 3 , Y 4 and Y 5 is N; Z 1 and Z 2 , which may be identical or different, are each CH or N; n is an integer from 1 to 3; R 1 is a C 3 -C 8 cycloalkyl group, a C 6 -C 10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R 2 and R 3 , which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C 3 -C 8 cycloalkyl group, a C 6 -C 10 aryl group, an aromatic heterocyclic ring, or the like; and R 4 is a hydrogen atom, a lower alkyl group, a C 3 -C 6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.