1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea

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Chemical Name:1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea
CAS No.:1350473-88-9
Molecular Formula:C₂₇H₁₈Cl₃N₅O₂
Molecular Weight:550.831
Hs Code.:

Synonyms:1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea

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Chemical Property of 1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea

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Technology Process of 1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea

There total 9 articles about 1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.6%

: 1350473-77-6
1-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea

: 1350473-88-9
1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea

Guidance literature:: 1-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1016/j.ejmech.2011.08.013

Reference yield:

: 342435-01-2
1-(4-chloro-3-methoxyphenyl)-2-(pyridin-4-yl)ethanone

: 1350473-88-9
1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: 18 h / 20 °C

1.2: 20 °C

2.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 90 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 20 °C

4.1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

5.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

With copper(l) iodide; palladium on activated charcoal; hydrogen; boron tribromide; potassium carbonate; L-proline; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.013

Reference yield:

: 116022-18-5
methyl 4-chloro-3-methoxybenzoate

: 1350473-88-9
1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -25 - 20 °C

2.1: 18 h / 20 °C

2.2: 20 °C

3.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 90 °C / Inert atmosphere

4.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 20 °C

5.1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

6.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

With copper(l) iodide; palladium on activated charcoal; hydrogen; boron tribromide; potassium carbonate; L-proline; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.013