342435-01-2

Basic information

• Product Name: 1-(4-chloro-3-methoxyphenyl)-2-(4-pyridinyl)ethanone
• Synonyms: 1-(4-chloro-3-methoxyphenyl)-2-(4-pyridinyl)ethanone
• CAS NO: 342435-01-2
• Molecular Weight: 261.708
• Mol File: 342435-01-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(4-chloro-3-methoxyphenyl)-2-(4-pyridinyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chloro-3-methoxyphenyl)-2-(4-pyridinyl)ethanone(342435-01-2)
• EPA Substance Registry System: 1-(4-chloro-3-methoxyphenyl)-2-(4-pyridinyl)ethanone(342435-01-2)

Safety Data

• Hazardous Substances Data: 342435-01-2(Hazardous Substances Data)

Usage

Abbreviation

CMEP

Physical state

Yellow-orange solid

Solubility

Soluble in organic solvents such as ethanol and methanol

Field of application

Medicinal chemistry and pharmaceutical research

Usage

Building block for the synthesis of various bioactive compounds

Properties

Exhibits anticonvulsant, analgesic, and anti-inflammatory properties

Potential therapeutic applications

Treating neurological disorders and pain management

Additional research

Studied for its potential role in modulating neurotransmitter signaling pathways, particularly in the context of addictive behaviors and substance abuse

Upstream product

• 73909-16-7 2-chloro-5-methylanisole 
• 85740-98-3 4-chloro-3-methoxybenzoic acid 
• 615-74-7 2-chloro-5-methylphenol 
• 108-89-4 picoline 
• 116022-18-5 methyl 4-chloro-3-methoxybenzoate 
• 342435-00-1 4-chloro-N,3-dimethoxy-N-methylbenzamide 

Downstream Products

• 1350473-75-4 4-[3-(4-chloro-3-methoxyphenyl)-1-(4-nitrophenyl)-1H-pyrazol-4-yl]pyridine 
• 1350473-76-5 4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine 
• 1350473-77-6 1-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea 
• 1350473-78-7 1-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(3,4-dichlorophenyl)urea 
• 1350473-79-8 1-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 1350473-80-1 1-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(3,5-bis(trifluoromethyl)phenyl)urea 
• 1421622-01-6 3,4-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide 
• 1350473-82-3 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide 
• 1350473-84-5 4-chloro-3-trifluoromethyl-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide 
• 1350473-86-7 3,5-bis(trifluoromethyl)-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide 
• 1350473-88-9 1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(2,3-dichlorophenyl)urea 
• 1350473-90-3 1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(3,4-dichlorophenyl)urea 
• 1350473-93-6 1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 1350473-95-8 1-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}-3-(3,5-bis(trifluoromethyl)phenyl)urea 

Relevant articles and documents

Evaluation of the inhibitory effects of pyridylpyrazole derivatives on lps-induced pge2 productions and nitric oxide in murine raw 264.7 macrophages

A series of thirteen triarylpyrazole analogs were investigated as inhibitors of lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2 ) and nitric oxide (NO) production in RAW 264.7 macrophages. The target compounds 1a–m have first

Antiproliferative diarylpyrazole derivatives as dual inhibitors of the ERK pathway and COX-2

A series of 3,4-diarylpyrazole-1-carboxamide derivatives was designed and synthesized. A selected group of the target compounds was tested for in vitro antiproliferative activities over a panel of 60 cancer cell lines at the National Cancer Institute (NCI, Bethesda, MD, USA) at a single-dose concentration of 10 μm, and the four most active compounds 9a, 9l, 9n, and 10o were further tested in a five-dose testing mode to determine their IC50 values over the 60 cell lines. In addition, a selected group of target compounds were tested for inhibitory effect over cyclooxygenase isozymes. Compounds 9a, 9l, 9n, and 10o were also tested for MEK and ERK kinase inhibitory activity using Western blot assay. Compound 10o was selective toward melanoma cell line subpanel, and its antiproliferative activity may be attributed to selective cyclooxygenase-2 inhibition and ERK pathway inhibition.

New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition, and molecular docking studies

Synthesis of a new series of diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold is described. Their in vitro antiproliferative activities against 9 human melanoma cell lines were tested. Compounds 12, 13, 15, and 21-23 showed the highe