(+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol

Base Information

• Chemical Name: (+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol
• CAS No.: 140438-65-9
• Molecular Formula: C₁₅H₁₆Cl₂N₆O₂
• Molecular Weight: 383.237
• Mol file: 140438-65-9.mol

Synonyms:(+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol

Chemical Property of (+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol

There total 6 articles about (+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.5%

p-chlorobenzenediazonium chloride (2028-74-2) + (+/-)-(1α,2β,4β)-4-<(2-amino-6-chloropyrimidin-4-yl)amino>-1,2-cyclopentanediol (140438-64-8) → (+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol (140438-65-9)

Guidance literature:

With sodium acetate; acetic acid; In water; Ambient temperature;

DOI:10.1021/jm00090a007

Reference yield:

cis-4-benzoylaminocyclopentene oxide (132065-13-5) → (+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol (140438-65-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 2percent aq.H₂SO₄ / 1 h / Ambient temperature

2: pyridine / Ambient temperature

3: 6N HCl / H₂O / 24 h / Heating

4: Et₃N / butan-1-ol / 48 h / Heating

5: 75.5 percent / AcONa*3H₂O, glacial AcOH / H₂O / Ambient temperature

With pyridine; hydrogenchloride; sulfuric acid; sodium acetate; acetic acid; triethylamine; In water; butan-1-ol;

DOI:10.1021/jm00090a007

Reference yield:

(+/-)-(1α,2β,4β)-4-amino-1,2-cyclopentanediol → (+/-)-(1α,2β,4β)-4-<<2-amino-6-chloro-5<(4-chlorophenyl)-azo>pyrimidin-4-yl>amino>-1,2-cyclopentanediol (140438-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / butan-1-ol / 48 h / Heating

2: 75.5 percent / AcONa*3H₂O, glacial AcOH / H₂O / Ambient temperature

With sodium acetate; acetic acid; triethylamine; In water; butan-1-ol;

DOI:10.1021/jm00090a007

upstream raw materials:

p-chlorobenzenediazonium chloride

(+/-)-(1α,2β,4β)-4-<(2-amino-6-chloropyrimidin-4-yl)amino>-1,2-cyclopentanediol

4-benzamidocyclopentene

(+/-)-(1α,2β,4α)-4-benzamidocyclopentane-1,2-diol

Downstream raw materials:

(+/-)-(1α,2β,4β)-4-(2,6-diamino-9H-purin-9-yl)-1,2-cyclopentanediol

(+/-)-2-amino-1,9-dihydro-9-<(1'α,3'β,4'β)-(3',4'dihydroxy-1'cyclopentyl)>-6H-purin-6-one