2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine

Base Information

Chemical Name:2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine
CAS No.:1334404-45-3
Molecular Formula:C₃₀H₃₇NO₃SSi
Molecular Weight:519.78
Hs Code.:

Synonyms:2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine

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Chemical Property of 2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine

Chemical Property:

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Technology Process of 2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine

There total 6 articles about 2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1334404-44-2
(R)-N-(1-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-4-[1,3]dioxolan-2-ylbutyl)-4-methylbenzenesulfonamide

: 1334404-45-3
2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine

Guidance literature:: With trifluoroacetic acid; In acetone; at 20 ℃;
DOI:10.1039/c1cc13048j

Reference yield:

: 934472-06-7
2-hydroxyethyl-1-(toluene-4-sulfonyl)aziridine

: 1334404-45-3
2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / tetrahydrofuran / 0 - 20 °C

2.1: copper(I) bromide dimethylsulfide complex / 2,3-dimercapto-succinic acid / 1 h / -78 °C

2.2: -78 - 20 °C

3.1: trifluoroacetic acid / acetone / 20 °C

With 1H-imidazole; copper(I) bromide dimethylsulfide complex; trifluoroacetic acid; In tetrahydrofuran; 2,3-dimercapto-succinic acid; acetone;
DOI:10.1039/c1cc13048j

Reference yield:

: N-(3-hydroxy-1-hydroxymethylpropyl)-4-methylbenzenesulfonamide

: 1334404-45-3
2-[2-((tert-butyl)diphenylsilanyloxy)ethyl]-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C

2.1: 1H-imidazole / tetrahydrofuran / 0 - 20 °C

3.1: copper(I) bromide dimethylsulfide complex / 2,3-dimercapto-succinic acid / 1 h / -78 °C

3.2: -78 - 20 °C

4.1: trifluoroacetic acid / acetone / 20 °C

With 1H-imidazole; copper(I) bromide dimethylsulfide complex; tributylphosphine; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 2,3-dimercapto-succinic acid; acetone; toluene; 1.1: Mitsunobu reaction;
DOI:10.1039/c1cc13048j